It is a very deep lake. It is best known for lake trout and chinook salmon fishing which are often caught via downriggers. It had decent kokanee salmon populations (fed the predators), but I believe that they have been in decline. Some of the feeder creeks have rainbows and brookies. The major feeder at the north end, the Stehekin River, has a good reputation but the fishable conditions are limited because the flows are dominated by snowmelt from the North Cascades. Steve
Smallmouth bass on the south end. Downrigging for Mackinaw and the landlocked Chinook is common. Trolling for Kokes has declined in recent years, they can still be seen spawning in the feeder creeks though. Rainbow trout can be caught pretty much all over the lake. Some of the feeder streams have Brooks and the native Westslope Cutthroat. You can also bottom fish for Burbot. Then of course theres the rough fish. The lake is inundated with Squawfish.