Most of my macro shots are done using a tripod, mup, and a remote release. I rarely use a flash. I shoot a Nikon D800e and it's ability to use high ISO with little noise allows me to increase ISO quite a bit for faster shutter speeds. Most DSLRs made recently (last year or two) you can boost the ISO up a bunch and not get much noise. I have shot inside of bars without flash using ISOs to 6400 or higher with acceptable results. I don't shoot anything like what Brady is doing though and can see how he needs flash.