At home the debate between the '06 and 270 was constant. One of the old hands said the 270 was a great gun depending on the dog you used...to retrieve the cripples. I believe Elmer Keith called the 270 a hunt and chase gun, but then he liked using a 300 winchester Mag for rock chuck! I personally have shot mule deer with a 280 (7mm express) a .308 and 06. the difference is like eating a sandwich hole, cut diagonally or horizontally. I would go with an 06 and find loads that work well for you and the rifle or if you will be hunting a lot of open areas I would consider one of the 300 Mags unless recoil bothers you then I would consider a 7mm Mag. When I was a kid one of my school mates took an elk with a single shot from a .243. His dad had to follow his for about a mile after a couple of hits with a .300 so I would agree that the important thing is how well you and the rifle connect.