With high neoprenes, I carry a double-stack .45 in a nylon shoulder holster. It's out of sight, under a vest or chest pouch. With breathables, I usually clip it over a femoral artery in a soft suede holster. (It sometimes falls out and down one leg, but at least it's still dry and with me.) Neither one affords a quick draw. A Cordura pouch holster sewn inside the top front of the waders might be better.