I'm offering on opinion and not an attack, got it?
I've had the opportunity/blessing to hunt a variety of animals using a variety of rifles and calibers. I've taken whitetail deer with .243, mule deer with .270 and .3006. I've taken moose with .3006 and .300 Win Mag. I've taken a dozen elk size and moose size animals with .3006, .300 Win Mag and .375H&H (300gr bullet). There was also a Cape buffalo with the .375. I've taken very small deer type animals (i.e. dog-size antelope) with .3006 and .375 H&H. I've shot targets and vermin with .22, ,22-250, and .223.
In all of these years and all of that hunting, I lost one wounded animal. The one wounded animal I lost was a blue wildebeest I shot through the chest with a 180gr .3006. It ran off, no blood trail, and we never found it. The following year I went back and shot another one through the chest with a .300 Win Mag and it ran 100 yards and dropped...and there was NO blood trail. The expert tracker found it. I saw another wildebeest shot with a .458 Lott using 400gr bullet and it staggered a little ways before it dropped.
I mention all of this, not to brag, but because these are my credentials.
My opinion is there seem to be folks who want to say "I shot this big/huge animal with this small caliber rifle.". The implication seems to be that the better hunters use smaller calibers. And this is where I strongly disagree.
In my opinion, a true sporting and ethical hunter uses the largest caliber they can effectively and accurately shoot to kill their game. We, as sportsmen/sportswomen, owe it to the animals we hunt. They deserve a clean, humane death. And, by the way, that is also why goose hunters use 12 gauges.
I also believe folks spend too much time focused on minute of angle accuracy off of the bench shooting those smaller rifles rather than trying to improve their skills to hit a paper plate at 150 yards offhand with a bigger rifle.
Robert Ruark said it best many years ago: Use Enough Gun.
By the way, if I ever decide to shoot another wildebeest, it will be with at least a .375.